Expression and secretion levels of Th1 and Th2 cytokines in patients with aggressive periodontitis.
Identifieur interne : 000286 ( Main/Exploration ); précédent : 000285; suivant : 000287Expression and secretion levels of Th1 and Th2 cytokines in patients with aggressive periodontitis.
Auteurs : J R Gonzales [Allemagne] ; Sabine Gröger ; Rolf-Hasso Boedeker ; Jörg MeyleSource :
- Clinical oral investigations [ 1436-3771 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Cytokines (métabolisme), Cytométrie en flux (MeSH), Expression des gènes (MeSH), Femelle (MeSH), Humains (MeSH), Interféron gamma (métabolisme), Interleukine-13 (métabolisme), Interleukine-2 (métabolisme), Interleukine-4 (métabolisme), Lymphocytes T CD4+ (MeSH), Lymphocytes auxiliaires Th1 (métabolisme), Lymphocytes auxiliaires Th2 (métabolisme), Mâle (MeSH), Parodontite agressive (génétique), Parodontite agressive (métabolisme), Réaction de polymérisation en chaine en temps réel (MeSH), Techniques de culture cellulaire (MeSH), Études cas-témoins (MeSH).
- MESH :
- génétique : Parodontite agressive.
- métabolisme : Cytokines, Interféron gamma, Interleukine-13, Interleukine-2, Interleukine-4, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Parodontite agressive.
- Adulte, Cytométrie en flux, Expression des gènes, Femelle, Humains, Lymphocytes T CD4+, Mâle, Réaction de polymérisation en chaine en temps réel, Techniques de culture cellulaire, Études cas-témoins.
English descriptors
- KwdEn :
- Adult (MeSH), Aggressive Periodontitis (genetics), Aggressive Periodontitis (metabolism), CD4-Positive T-Lymphocytes (MeSH), Case-Control Studies (MeSH), Cell Culture Techniques (MeSH), Cytokines (metabolism), Female (MeSH), Flow Cytometry (MeSH), Gene Expression (MeSH), Humans (MeSH), Interferon-gamma (metabolism), Interleukin-13 (metabolism), Interleukin-2 (metabolism), Interleukin-4 (metabolism), Male (MeSH), Real-Time Polymerase Chain Reaction (MeSH), Th1 Cells (metabolism), Th2 Cells (metabolism).
- MESH :
- chemical , metabolism : Cytokines, Interferon-gamma, Interleukin-13, Interleukin-2, Interleukin-4.
- genetics : Aggressive Periodontitis.
- metabolism : Aggressive Periodontitis, Th1 Cells, Th2 Cells.
- Adult, CD4-Positive T-Lymphocytes, Case-Control Studies, Cell Culture Techniques, Female, Flow Cytometry, Gene Expression, Humans, Male, Real-Time Polymerase Chain Reaction.
Abstract
The role of Th1 and Th2 cytokines in the pathogenesis of aggressive periodontitis has not been previously examined. The aim of this study was to analyse the expression and production of IL-2, IFN-γ, IL-4 and IL-13 in CD4+ cells from the peripheral blood of patients with aggressive periodontitis (AgP) and periodontally healthy controls. Gene expression was analysed in inactivated and activated CD4+ cells by real-time PCR. Cells were activated for 4, 8 and 24 h with anti-CD3/CD28 antibody, phytohemagglutinin (PHA), and Porphyromonas gingivalis (P.g.) outer membrane protein (OMP). Protein levels were measured in supernatants of activated CD4+ cells by bead-based immunoassay (CBA). Statistics were performed using U test (p < 0.05). In controls, IL-4 expression was increased in inactivated CD4+ cells (p = 0.05), and IFN-γ and IL-2 expressions were increased in activated CD4+ cells: IFN-γ with anti-CD3/anti-CD28, P.g. OMP and PHA (p < 0.05); IL-2 with P.g. OMP and PHA (p < 0.05). In patients, although IL-4 and IL-13 expressions were higher in activated CD4+ cells, there were no differences compared to controls. The production of IL-4 and IL-2 was higher in the patients' CD4+ cells activated with PHA (p < 0.05). Although the results showed a predominantly Th1 mRNA profile in activated CD4+ cells of controls, protein concentrations showed no clear Th1 or Th2 profiles. The functional pathways of the Th cell immune response in aggressive periodontitis are still not well understood in order to develop individualised diagnostic and treatment plans.
DOI: 10.1007/s00784-011-0634-8
PubMed: 22065246
Affiliations:
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The aim of this study was to analyse the expression and production of IL-2, IFN-γ, IL-4 and IL-13 in CD4+ cells from the peripheral blood of patients with aggressive periodontitis (AgP) and periodontally healthy controls. Gene expression was analysed in inactivated and activated CD4+ cells by real-time PCR. Cells were activated for 4, 8 and 24 h with anti-CD3/CD28 antibody, phytohemagglutinin (PHA), and Porphyromonas gingivalis (P.g.) outer membrane protein (OMP). Protein levels were measured in supernatants of activated CD4+ cells by bead-based immunoassay (CBA). Statistics were performed using U test (p < 0.05). In controls, IL-4 expression was increased in inactivated CD4+ cells (p = 0.05), and IFN-γ and IL-2 expressions were increased in activated CD4+ cells: IFN-γ with anti-CD3/anti-CD28, P.g. OMP and PHA (p < 0.05); IL-2 with P.g. OMP and PHA (p < 0.05). In patients, although IL-4 and IL-13 expressions were higher in activated CD4+ cells, there were no differences compared to controls. The production of IL-4 and IL-2 was higher in the patients' CD4+ cells activated with PHA (p < 0.05). Although the results showed a predominantly Th1 mRNA profile in activated CD4+ cells of controls, protein concentrations showed no clear Th1 or Th2 profiles. The functional pathways of the Th cell immune response in aggressive periodontitis are still not well understood in order to develop individualised diagnostic and treatment plans.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22065246</PMID><DateCompleted><Year>2015</Year><Month>11</Month><Day>05</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1436-3771</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>5</Issue><PubDate><Year>2012</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Clinical oral investigations</Title><ISOAbbreviation>Clin Oral Investig</ISOAbbreviation></Journal><ArticleTitle>Expression and secretion levels of Th1 and Th2 cytokines in patients with aggressive periodontitis.</ArticleTitle><Pagination><MedlinePgn>1463-73</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00784-011-0634-8</ELocationID><Abstract><AbstractText>The role of Th1 and Th2 cytokines in the pathogenesis of aggressive periodontitis has not been previously examined. The aim of this study was to analyse the expression and production of IL-2, IFN-γ, IL-4 and IL-13 in CD4+ cells from the peripheral blood of patients with aggressive periodontitis (AgP) and periodontally healthy controls. Gene expression was analysed in inactivated and activated CD4+ cells by real-time PCR. Cells were activated for 4, 8 and 24 h with anti-CD3/CD28 antibody, phytohemagglutinin (PHA), and Porphyromonas gingivalis (P.g.) outer membrane protein (OMP). Protein levels were measured in supernatants of activated CD4+ cells by bead-based immunoassay (CBA). Statistics were performed using U test (p < 0.05). In controls, IL-4 expression was increased in inactivated CD4+ cells (p = 0.05), and IFN-γ and IL-2 expressions were increased in activated CD4+ cells: IFN-γ with anti-CD3/anti-CD28, P.g. OMP and PHA (p < 0.05); IL-2 with P.g. OMP and PHA (p < 0.05). In patients, although IL-4 and IL-13 expressions were higher in activated CD4+ cells, there were no differences compared to controls. The production of IL-4 and IL-2 was higher in the patients' CD4+ cells activated with PHA (p < 0.05). Although the results showed a predominantly Th1 mRNA profile in activated CD4+ cells of controls, protein concentrations showed no clear Th1 or Th2 profiles. The functional pathways of the Th cell immune response in aggressive periodontitis are still not well understood in order to develop individualised diagnostic and treatment plans.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gonzales</LastName><ForeName>J R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Periodontology, Justus-Liebig-University, Schlangenzahl 14, 35392 Giessen, Germany. jose.gonzales@dentist.med.uni-giessen.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gröger</LastName><ForeName>Sabine</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Boedeker</LastName><ForeName>Rolf-Hasso</ForeName><Initials>RH</Initials></Author><Author ValidYN="Y"><LastName>Meyle</LastName><ForeName>Jörg</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal 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Hasso" sort="Boedeker, Rolf Hasso" uniqKey="Boedeker R" first="Rolf-Hasso" last="Boedeker">Rolf-Hasso Boedeker</name><name sortKey="Groger, Sabine" sort="Groger, Sabine" uniqKey="Groger S" first="Sabine" last="Gröger">Sabine Gröger</name><name sortKey="Meyle, Jorg" sort="Meyle, Jorg" uniqKey="Meyle J" first="Jörg" last="Meyle">Jörg Meyle</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Gonzales, J R" sort="Gonzales, J R" uniqKey="Gonzales J" first="J R" last="Gonzales">J R Gonzales</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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